J. Warren Beach, Ph.D. Associate Professor Pharmaceutical and Biomedical Sciences Office: Room 375, R.C. Wilson Pharmacy Phone: (706) 542-5382 E-mail: wbeach@rx.uga.edu

Biosketch

B.S. Chemistry	Erskine College	Due West, SC	1979
B.S. Pharmacy	Medical University of South Carolina	Charleston, SC	1982
Ph.D. Medicinal Chemistry	University of Florida	Gainesville, FL	1987
Post-Doctoral Fellow, Drug Discovery Group, College of Pharmacy	University of Georgia	Athens, GA	1988-1989
Research Associate, Drug Discovery Group	University of Georgia	Athens, GA	1989-1992
Assistant Professor	University of Georgia	Athens, GA	1992-1999
Graduate Coordinator, Dept of Medicinal Chemistry	University of Georgia	Athens, GA	1995-1997
Associate Professor	University of Georgia	Athens, GA	1999-Present
Core Member/Alzheimer's Research Cntr	Medical College of Georgia	Augusta, GA	1999-present

Honors and Awards
G.E. Philbrook Teaching Award for Outstanding Undergraduate Teaching presented by the Northeast Georgia Section of the American Chemical Society, 2001-2002
College of Pharmacy Teacher of the Year Award, 1998 and 2005
Phi Delta Chi Pharmaceutical Fraternity Teacher of the Year in 1993, 1995, and 2003

Research Interests
Design and synthesis of neuroprotective agents based on choline and nicotine for the treatment of neuro-degenerative disease such as Alzheimer’s and Parkinson’s diseases

Representative Publications
J.J. Buccafusco, J.W. Beach, A.V. Terry, G.S. Doad, A. Sood, E. Arias, H. Misawa, M. Masai, T. Fujii, K. Kawashima, Novel analogs of choline as potential neuroprotective agents Journal of Alzheimers Disease, 2004 6 (6) S85-S92 Suppl.

A. Storch, Y. I. Hwang, D. A. Gearhart, J. W. Beach, E. J. Neafsey, M. A. Collins and J. Schwarz, Dopamine transporter-mediated cytotoxicity of - carbolinium derivatives related to Parkinson’s disease: relationship to transporter-dependent uptake. Journal of Neurochemistry, 2004, 89, 685–694.

R.R. Jonnala, J.H. Graham III, A.V. Terry Jr., J.W. Beach, J.A. Young and J.J. Buccafusco, Relative Levels of Cytoprotection Produced by Analogs of Choline and the Role of α-Nicotinic Acetylcholine Receptors. Synapse, 2003, 47, 262-269.

D.A. Gearhart, P.F. Toole and J.W. Beach , Identification of Brain Proteins that Interact with 2-Methylnorharman, an Analog of the Parkinsonian-Inducing Toxin, MPP+, Neuroscience Research, 2002, 44, 255-265.

J.W. Beach, M.I. Damaj, M. Jonnala, A.V. Terry and J.J. Buccafusco, Synthesis and In Vivo and In Vitro Evaluation of Isoarecolone and Derivatives, Medicinal Chemistry Research, 1998, 8, 510-522.

T.L. Metting, D.E. Burgio, A.V. Terry Jr., J.W. Beach, C.R. McCurdy and D.D. Allen, Inhibition of Brain Choline Uptake Isoarecolone and Lobeline Derivatives: Implications for Vector- Mediated Brain Drug Delivery, Neuroscience Letters, 1998, 258, 25-28.


Chapters in Books
C.R. McCurdy, R. Miller, J.W. Beach, Lobeline: A Natural Product With High Affinity for Neuronal Nicotinic Receptors and a Vast Potential for Use in Neurological Disorders. In: Biologically Active Natural Products: Agrochemicals and Pharmaceuticals, Ed, H.C. Cutler and S.J. Cutler. CRC Press, 1999, p. 151-162.